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Original: Shi Juan returns to the park

As double 11 approaches, many people have already filled their shopping carts with health care products in advance, just waiting for the zero discount time to start shooting. Among them, one of the hottest and most publicized commodities is probably imported joint health care products. However, the latest research proves that the key ingredients in joint health care products may not be as useful as placebos. At the same time, because its formula changes at will, its medicinal properties and toxicity are also difficult to monitor. Friends who want to buy such health care products at special prices need to think twice before you do.

Today’s two articles bring together some kinds of goods that should be bought carefully or even not. Among them, the e-cigarettes that we strongly warned about were completely removed from Taobao and Tmall on November 6. So far, the online sales platform has completely banned the sale of e-cigarettes.

Writing | Shi Juan

Maybe you exercise a lot, maybe you need to sit still for a long time because of your work, or maybe you are old. In either case, the concept of protecting your joints must be familiar.

Known as a health care product that is good for joints, the most popular brand at present is Move Free, which is a brand of Schiff, a famous American health care company. Common models are as follows:

Image from Schiff official website

Costco, a famous American supermarket, also has several kinds that people often buy.

Image from CVS official website

The main components of these drugs are glucosamine and chondroitin sulfate. Some of them are added with vitamin D or an organic sulfur compound: dimethyl sulfone (MSM, an essential substance for human collagen synthesis).

Glucosamine claims to "strengthen, protect and rebuild joints", while chondroitin sulfate "can help lubricate and cushion joints", thus finally relieving joint pain, joint stiffness and arthritis.

I believe everyone has read many online articles recommending this health care product (the screenshot is omitted here).

However, are glucosamine and chondroitin sulfate really good for joints?

One study after another published in authoritative magazines shows that glucosamine and chondroitin sulfate health care products have no effect on joints. Even in the United States, there are several class actions, accusing the manufacturers of these health care products of making false advertisements, misleading and deceiving ordinary consumers [1, 2].

Photo: In June 2019, consumers collectively sued Schiff Move Free for false advertising and formally filed a case. [2]

A series of studies, the answer is getting clearer and clearer.

The most famous research is called Gait (Glucosamine/Chondroitin Arthritis Intervention Trial), which took four years and cost $12.5 million. It was funded by two departments under the National Institutes of Health (NIH), namely National Center for Complementary and Alternative Medicine (NCCAM) and National Institute of Arthritis/Musculoskeletal/Dermatology (NIAMS).

The purpose of this study is to determine whether glucosamine and chondroitin sulfate are effective in the treatment of osteoarthritis.

Let’s take out these studies and analyze them for everyone.

one

This study was published in the authoritative medical journal New England Medicine in 2006 [3].

A total of 1583 patients with osteoarthritis were recruited and randomly assigned to take:

Placebo (the same shape as medicine, but without the ingredients of medicine, it can be simply understood as sugar ball)

1,500 milligrams of glucosamine per day

1200 mg chondroitin sulfate per day

1500 mg glucosamine +1200 mg chondroitin sulfate per day

200 mg of prescription drug celebrex (an analgesic used to relieve pain for arthritis and other diseases) every day.

It is worth noting that this dose is the dose of glucosamine and chondroitin sulfate in popular health care products at that time. It is emphasized here that there was a reason for the dose in health care products at that time, which will be further explained later.

If the patient feels that the joint pain is still uncontrollable, he can take up to 4000 mg of acetaminophen (the main component of Tylenol) every day.

The main purpose of the study is to see if the pain in the knee joint is reduced by 20% after taking the medicine for 24 weeks.

The result is as follows:

It can be seen that there is no significant difference between the group taking glucosamine and chondroitin sulfate and the placebo group.

However, it is worth noting that at 24 weeks, 60.1% (more than half) people who took placebos also felt that their symptoms had improved. This extraordinary placebo effect is often seen in clinical trials of arthritis. Without knowing what they are eating, patients think they are taking useful drugs, and strong psychological hints will make the pain less intense.

Source: The-Science-Site.com.

This trial is a good example to explain why clinical trials are rigorous only if they are randomized and double-blind. Randomized double-blind trials should make sure that there is basically no difference in appearance between the pills in the placebo group and the real pills. The people who eat them can’t guess what they are eating at all, and the people who collect data don’t know what each patient is eating, so as to ensure that there will be no bias in the data collection process.

After taking celebrex for 24 weeks, those who felt that their pain was reduced by 20% were about 10% higher than those in the placebo group, achieving a statistically significant effect. Once again, it proves that this prescription drug is effective.

Finally, the author of this study divided the patients into groups according to the severity of symptoms, and found that the combined therapy of 1500 mg glucosamine and 1200 mg chondroitin sulfate/day seems to have certain effect on patients with severe symptoms. However, it is worth noting that the number of volunteers with severe symptoms in this study is relatively small, and the sample size is too small to be conclusive, which needs further research to confirm.

2

So, these authors continued to study. The new results were published in the journal Arthritis and Rheumatism in 2008 [4]. We call it study 2 (the last one was called study 1).

The time of the second study was extended from 24 weeks to 24 months (two years), and the patients with severe symptoms were studied emphatically, because the last short-term trial found that the combination therapy of glucosamine and chondroitin sulfate might be useful for these patients.

572 patients with moderate or severe knee osteoarthritis were recruited and randomly divided into five groups:

placebo

Glucosamine (500 mg each time, 3 times a day: 1500 mg/day)

Chondroitin sulfate (400 mg each time, 3 times a day: 1200 mg/day)

Glucosamine (500 mg each time, 3 times a day)+chondroitin sulfate (400 mg each time, 3 times a day)

Celebrex (200 mg once a day)

The final effective index of this experiment is not the subjective pain feeling in the first experiment (this kind of patient’s feeling is the most prone to error), but the change of joint space width is determined by X-ray at 24 months. The more severe osteoarthritis is, the more cartilage loss is, and the smaller joint space is. If a drug can stop or even reverse the shortening of joint space, it can improve the joint structure and relieve symptoms.

Finally, in the second study, the average joint spacing of patients with osteoarthritis in the placebo group decreased by 0.166 mm after two years, which meant that osteoarthritis was aggravated.

Compared with placebo, glucosamine, chondroitin sulfate or their combination therapy did not significantly reduce the loss of joint space width (arthritis did not relieve).

The researchers even observed that the joint space shortening (arthritis aggravation) of combined therapy was more serious than that of other groups, probably because taking two drugs at the same time affected the absorption of each drug-and most health care products on the market mixed these two ingredients together.

three

The final result of the GAIT study was published in Rheumatology Annual Report in 2010 [5]. We call it study three.

The third study was similar to the first study, except that the experiment was extended from 24 weeks to 24 months.

This time, the researcher recruited 662 volunteers with moderate to severe osteoarthritis and randomly divided them into five groups as in the second paper. The main index is, as in the first study, to see whether the pain of knee joint is reduced by 20% compared with that before taking medicine.

The results of this long-term experiment are similar to those of study 1. All groups had significant pain and functional improvement within 2 years. However, no treatment is significantly better than placebo. There was no statistically significant difference between the treatment groups, which once again proved the powerful placebo effect.

The good news is that no serious side effects were observed in all the treatment groups-it seems that these drugs are safe to take for at least two years in this experiment.

GAIT research tells us:

1. The curative effect of glucosamine and chondroitin sulfate comes from strong psychological suggestion to a great extent. Even if you eat "sugar balls", if you think you are eating drugs that are useful for joints, more than half of people will feel that joint pain is reduced.

2. Taking glucosamine and chondroitin sulfate at the same time may affect the absorption of any single component.

3. Glucosamine and chondroitin sulfate can not improve the shortening of joint space after illness.

four

The latest study on glucosamine and chondroitin sulfate was completed in 2016 [6]. This experiment recruited 164 patients with knee pain caused by osteoarthritis, and half of them took glucosamine (1500 mg/day) and chondroitin sulfate (1200 mg/day). The other half took a placebo.

However, the study was terminated early for an unusual reason: compared with the placebo group, the symptoms of patients who took glucosamine and chondroitin sulfate worsened.

Further than the previous three experimental results, this result suggests a terrible possibility: taking glucosamine and chondroitin sulfate may make the joint condition worse than doing nothing.

Move Free, hepatotoxicity?

I often hear friends around me say that most people eat health care products without any side effects. What if they eat them? If you don’t eat, don’t you miss that "one thousand" opportunity?

However, have you overlooked the "one thousand" harmful situation?

In fact, there are no published prospective studies on the efficacy, tolerance and safety of most health care products.

Remarks:

Prospective study usually involves observing a group of subjects for a long time, and studying whether some observed results (such as illness) are related to other factors (such as suspicious risks or protective factors) during the trial. The prospective study related to the safety of health products mentioned here is to observe whether a group of people who eat health products will have some adverse reactions related to eating health products.

This is because the ingredients of health care products are not strictly monitored by FDA, and the formula can be changed frequently. This not only makes it difficult to study its security, but also means that its security is even more insecure. Who knows which batch of formula will go wrong?

Take the current Schiff Move Free series products as an example.

If you look closely at the website of Schiff Nutrition International, the manufacturer of Move Free, you will find that there is a small line below:

“Our packaging and/or formulas change from time to time. Please refer to the actual packaging for current product information.”

Our packaging and/or formula will change from time to time. Please refer to the actual packaging for current product information. "

Figure: Composition description of a Move Free product on Schiff Nutrition International website.

At present, many cases have been reported, saying that patients taking Move Free have obvious liver damage in clinic.

In 2010, the first case report on liver injury caused by taking Move Free was published in the United States [7]. Subsequently, new cases were reported in August 2012 and September 2013. In these published cases, patients developed acute hepatocyte injury within 1-3 weeks after taking a Move Free product. The degree of injury is moderate and can be relieved within 1 to 2 months after stopping taking it; There is no immune allergy and autoimmune reaction, and it can finally recover completely in all cases. However, one patient resumed using the product when he was half well, and immediately developed acute liver injury with similar symptoms. In addition, although no more cases have been published, there are three prospective studies on drug-induced hepatotoxicity in the United States, all of which mentioned acute liver injury cases related to Move Free, all of which occurred in 2012-2013 [October 12].

The specific Move Free products mentioned in these cases at that time, in addition to the main glucosamine and chondroitin sulfate, also contained a patented herbal mixture, including China Scutellaria baicalensis and Acacia catechu.

These reports attributed the liver injury caused by Move Free to Scutellaria baicalensis Georgi in China [13], and only one case was attributed to glucosamine [11]. However, China Scutellaria baicalensis Georgi protects the liver in animal models, but not damages it [14-16]. Why can it cause human liver injury? The report did not reasonably explain its mechanism of liver injury. There is also a kind of explanation that the China Scutellaria baicalensis Georgi in Move Free contains pollutants, or maybe it is not China Scutellaria baicalensis Georgi at all (the manufacturer made a mistake and added a similar plant as China Scutellaria baicalensis Georgi).

Therefore, it is still uncertain what specific components may cause liver injury. Manufacturers often change the composition and concentration of health care products, so it is not certain whether the products currently on the market still contain these harmful ingredients. At present, Move Free series products no longer list "including China Scutellaria baicalensis Georgi and other herbal ingredients", but give a patented ingredient with a new name on some products, which is called "uniflex (fruitex-b calcium fruitoborate)", claiming to be a mineral extracted from vegetables and fruits.

What’s more noteworthy is that the content of chondroitin sulfate in the Move Free series products listed on the official website in the United States has been greatly reduced (see the figure below), and the dosage has been reduced from 1200mg per day to 200mg per day. There is no glucosamine and chondroitin sulfate in the Move Free Ultra series products, one of which only contains calcium and calcium borate, and the other contains a patented cartilage mixture. However, most of them are produced by different manufacturers, such as similar products of Kirkland brand sold by Costco, and the dosage is still 1500 mg of glucosamine and 1200 mg of chondroitin sulfate every day.

Figure: The ingredients of four existing Move Free series products (from official website, USA) are chondroitin sulfate content in the red box. Click to see a bigger picture.

Figure: Components of four existing Move Free Ultra series products (from official website, USA).

In addition, a small study in 2013 found that taking glucosamine may increase the risk of glaucoma, which will threaten vision if it is not treated in time [17]. Chondroitin sulfate can play the role of blood anticoagulant, so it may cause internal bleeding.

Another problem that is often overlooked is drug interaction: any combination of compounds may produce bad interactions. If you are taking other drugs, you must decide carefully whether to take health care products. Because they may not contain the amount indicated on the label, or they may contain pollutants-this will make it more difficult for you to accurately judge whether there will be drug interactions.

Other side effects of glucosamine and chondroitin sulfate include:

Heartburn, heartburn

feel tired and sleepy

headache

Allergic reaction (especially if you are allergic to shellfish)

What drugs/treatments are there for arthritis?

So far, there is no therapy or medicine that can cure arthritis.

There are many drugs that can be used to improve symptoms (mainly to relieve pain) and slow down the deterioration of the disease, but they cannot completely reverse the structural damage.

Because there are more than 100 different kinds of arthritis, each specific type of treatment is not exactly the same. We should prescribe the right medicine after diagnosis.

After the doctor looked around and guessed the type of arthritis he might have, there were two main methods for further diagnosis:

1. Body fluid analysis. Analyzing blood, urine and joint fluid can help determine what type of arthritis you may have. In order to obtain a sample of joint fluid, doctors usually need to put a needle into the joint space to suck some fluid.

2. Imaging analysis. Commonly used imaging methods include X-ray, CT, magnetic resonance imaging (MRI) and ultrasound.

After confirming the type of arthritis, you may need to try several different treatments or combinations of treatments to find the one that suits you best.

There are usually three types of therapies: drugs, physical therapy and surgery.

01

medicine

Different types of arthritis, should use different drugs. Commonly used arthritis drugs include:

Analgesics These drugs help to relieve pain, but they can’t diminish inflammation. For example, acetaminophen (the main component of Tylenol), Ultram (Ultracet), and some strictly regulated painkillers (such as oxycodone).

Non-steroidal anti-inflammatory drugs (NSAIDs). These drugs can relieve pain and diminish inflammation at the same time. Over-the-counter NSAID include ibuprofen (Motrin) and naproxen sodium (Aleve). Some types of NSAID must be obtained by prescription. Oral NSAID may cause stomach upset, and some may increase the risk of heart attack or stroke. Some NSAID can also be rubbed on joints as creams or gels. I have talked about the points for attention in the use of Tylenol and Ibuprofen before. If you are interested, you can go and see it (→ How to use Tylenol and Ibuprofen correctly? | 117 threesome).

Anti-irritant Some kinds of ointment contain menthol or capsaicin. Rubbing these ointments on the skin of painful joints may interfere with the transmission of pain signals, thus achieving the effect of relieving pain.

Antirheumatic drugs. Usually used to treat rheumatoid arthritis, it can slow down or prevent the immune system from attacking joints. Such as methotrexate (Trexall) and hydroxychloroquine.

Specific immune response modulators. It is usually used with anti-rheumatic drugs, which target certain protein molecules involved in immune response. Such as etanercept (Enbrel) and infliximab (Remicade).

Corticosteroids. These drugs, including prednisone and cortisone, can reduce inflammation and suppress the immune system. Corticosteroids can be administered orally or directly into joints.

02

physiotherapy

Physical therapy is helpful for some types of arthritis. Moderate exercise can improve and strengthen the muscles around the joints.

03

operation

If nothing works, it will be operated. Include joint repair or joint replacement.

04

Acupuncture, yoga, Tai Ji Chuan and massage.

There is little data to support these unconventional treatments, but there is no conclusive evidence that they are ineffective. You can look at your own reaction to see if you try.

Total knot

Although there is no convincing data to prove that health products containing glucosamine and chondroitin sulfate are beneficial to joints, many people will buy and take them. Some people think that even if there is no effect from the overall data of the population, it may be useful for individuals because of some factors; Others believe that even if most of the effects come from the placebo effect, the benefits of the placebo effect are real and hard to give up.

However, the latest clinical results and several cases of side effects show that these health care products may also be harmful to health. Manufacturers often change the formula, and the actual ingredients and dosage may be far from what you expected.

Most types of arthritis are chronic and will affect life-long diseases. Knowing all kinds of risk factors (including obesity, sedentary lifestyle, eating habits, joint injuries, smoking, etc.), changing lifestyle and reducing the chance of getting sick are the best preventive measures. It is absolutely unacceptable to put all your hopes on health care products without fundamentally changing your living habits.

references

[1] https://topclassactions.com/lawsuit-settlements/consumer-products/supplements/900914-move-free-supplement-buyers-get-class-cert-false-ad-lawsuit/

[2] https://topclassactions.com/lawsuit-settlements/lawsuit-news/791647-schiff-move-free-class-action-says-joint-health-supplements-dont-work/

[3] D. O. Clegg et al., Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 354, 795-808 (2006).

[4] A. D. Sawitzke et al., The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/ chondroitin arthritis intervention trial. Arthritis Rheum 58, 3183-3191 (2008).

[5] A. D. Sawitzke et al., Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT. Ann Rheum Dis 69, 1459-1464 (2010).

[6] J. A. Roman-Blas et al., Combined Treatment With Chondroitin Sulfate and Glucosamine Sulfate Shows No Superiority Over Placebo for Reduction of Joint Pain and Functional Impai rment in Patients With Knee Osteoarthritis: A Six-Month Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Arthritis & Rheumatology 69, 77-85 (2017).

[7] S. A. Linnebur, O. C. Rapacchietta, M. Vejar, Hepatotoxicity associated with chinese skullcap contained in Move Free Advanced dietary supplement: two case reports and review of the literature. Pharmacotherapy 30, 750, 258e-262e (2010).

[8] L. Yang, A. Aronsohn, J. Hart, D. Jensen, Herbal hepatoxicity from Chinese skullcap: A case report. World J Hepatol 4, 231-233 (2012).

9. R. Dhanasekaran, V. Owens, W. Sanchez, Chinese skullcap in move free arthritis supplement causes drug induced liver injury and pulmonary infiltrates. Case Reports Hepatol 2013, 965092-965092 (2013).

[10] V. J. Navarro et al., Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network. Hepatology (Baltimore, Md.) 60, 1399-1408 (2014).

[11] S. Rossi, V. J. Navarro, Herbs and Liver Injury: A Clinical Perspective. Clinical Gastroenterology and Hepatology 12, 1069-1076 (2014).

[12] N. Chalasani et al., Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study. Gastroenterology 148, 1340-1352.e1347 (2015).

[13] V. J. Navarro, L. B. Seeff, Liver Injury Induced by Herbal Complementary and Alternative Medicine. Clinics in Liver Disease 17, 715-735 (2013).

[14] Q. Dong et al., Scutellaria baicalensis Georgi extract protects against alcohol?induced acute liver injury in mice and affects the mechanism of ER stress. Mol Med Rep 13, 3052-3062 (2016).

[15] J. Boer et al., Protection against aflatoxin-B-1-induced liver mutagenesis by Scutellaria baicalensis. Mutation research 578, 15-22 (2005).

[16] H. N. Thanh et al., Ethanol extracts of Scutellaria baicalensis protect against lipopolysaccharide-induced acute liver injury in mice. Asian Pacific Journal of Tropical Biomedicine 5, 761-767 (2015).

[17] R. K. Murphy et al., Oral Glucosamine Supplements as a Possible Ocular Hypertensive Agent. JAMA Ophthalmology 131, 955-957 (2013).

The pen name is "Cats at My Will" and now lives in Boston, USA. I graduated from the Department of Biological Sciences and Technology in Tsinghua University with a bachelor’s degree, and joined a multinational well-known pharmaceutical company to engage in drug research and development after obtaining a doctorate in the United States. For more than ten years, he led the team to fight diabetes and muscular dystrophy. In recent years, he focused on the research and development of anti-aging drugs. Personal WeChat WeChat official account "Feel Free" to talk to you about medical care.

Shi Juan

END

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Original title: "double 11 carefully buys joint health products: the formula is changed at will, and the effect is not as good as placebo | 117 threesome"

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[Hangzhou, May 10, 2022] On May 10, the latest technological achievement of the global self-research of the zero-run automobile, the zero-run C01, made its debut and officially started the pre-sale. Focusing on the mid-to-high-end car market and meeting the needs of users for multi-scene cars, C01 has released five configuration versions, namely, 500 standard endurance version, 606 long endurance version, 717 long endurance version, 630 Pro performance version and 630 Pro high performance version, with the pre-sale price range of 180,000-270,000. At the same time, Zero Car launched the "0 yuan Reservation" C-level courtesy for C01. During the pre-sale period, it was decided that the first owner could enjoy the lifetime warranty of Sandian.

Zhu Jiangming, the founder of Zero Run Car, said at the press conference that "C01 is a luxury electric car for Chinese people". Zero-run C01 is positioned as a fully intelligent multi-scene electric car. Relying on the advantages of global self-developed technology, it builds the bottom strength with the core highlight of "1357"-equipped with the world’s first battery-free CTC technology, with an acceleration performance of 3.66 seconds, the size of a medium and large car of 5050*1902*1509mm, and the battery life of CLTC under comprehensive working conditions is as high as 717 kilometers. C01 brings advanced experience with advanced technology, and will refresh the market value standard of mid-to-high-end cars with the strength of C-bit wisdom, C-bit design and C-bit character, so as to help users improve their life.

[Zhu Jiangming, founder and chairman of Zero Run Technology]

C-bit wisdom: intelligent cubic to achieve exponential improvement of wisdom

Adhering to the global self-research route, all the key software and hardware in the core system and electronic components of intelligent electric vehicles have been developed by zero-running, and the complete body of intelligent electric vehicles has been built around intelligent power, intelligent cockpit and intelligent driving. Zero-run C01, as the latest achievement of global self-research of zero-run vehicles, fully embodies the intelligent product concept.

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—— 28 high-precision sensing hardware and 23 intelligent driving assistance functions are standard, and NAP intelligent navigation assistance system can be subscribed. Covering all the scenes such as daily city driving, high-speed long-distance self-driving, parking lot parking, traffic lights and traffic jams, it provides full-time and all-round driving assistance for users to travel. AR real-life navigation realizes the integration of actual road conditions and navigation information on the central control screen, and the navigation experience is greatly improved. APA intelligent parking system can realize one-button automatic parking inside the car, door handle parking outside the car and remote automatic parking outside the car, which is suitable for various parking scenarios. The NAP intelligent navigation assistance system matched with high-precision map can realize the functions of autonomous on-ramp entry, optimal lane planning, autonomous overtaking and automatic speed limit adjustment according to navigation.

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C-position design: natural aesthetics of science and technology, creating a rich internal car.

C01 takes the natural aesthetics of science and technology as the design concept, and does subtraction in modeling. Cao Li, vice president of Zero Run Technology, shared at the press conference: "The natural aesthetics of science and technology is the design language of zero run cars. We hope that through scientific and rational thinking, innovative technologies will be integrated into a gentle and elegant perceptual appearance to create a rich internal car, so that C01 will bring more temperature touches to users at the perceptual level."

[Cao Li, Vice President of Zero Run Technology]

Abandoning redundant and complicated line design, C01 uses elegant and powerful profile to reduce visual load, and the use of space-time capsule symbols makes the overall style naturally unified. The fully enclosed front face is matched with the through headlight design, which highlights the new trend of science and technology. Digital crystal headlights have the dynamic effects of running water and breathing, and support a variety of lighting modes; The luminous Logo at the rear of the car is embedded in the penetrating taillights, which is scientific and exquisite. Slip-back modeling body, borderless doors, hidden door handles, and high-pitched duck tail design not only make the whole vehicle dynamic, but also achieve ultra-low wind resistance at the same level.

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C character: leapfrog extrasensory configuration brings luxury car-class driving experience

The retail C01 brings millions of enjoyment to users at the price of 180,000-270,000 yuan. No matter the taste of driving, the fun of driving and control, and the safety protection, we will not lose millions of luxury cars, fully satisfying users’ pursuit of taste and grade in multiple scenarios.

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[The only rear electric boss at the same level]

The Zero Run C01 has an immersive music cockpit comparable to a luxury car, and the entertainment experience is the best in its class. 12-speaker Hi-Fi surround sound system, tuned by professional tuning team in Agamis, France, 3D sound effects, and seven kinds of sound stage, bringing the enjoyment like a concert hall. Lei Shi car KTV system, with exclusive custom microphone, makes the cockpit turn into a karaoke room in seconds. It is worth mentioning that the zero-run C01 audio system also supports OTA upgrade, which is always new.

In terms of handling pleasure, the zero-run C01′ s rear-drive structure, front double wishbone, rear five-bar luxury car suspension, and the high-performance version equipped with 20-inch wheels, together with the high-rigidity lightweight body brought by CTC, make the handling and driving quality of the whole vehicle comparable to that of millions of luxury cars.

In terms of safety, the standard 23 intelligent driving assistance functions, combined with the mainland MK100?ESC High Plus body stability control system, enable the zero-run C01 to have the leading active safety at the same level, which can avoid dangerous situations to the maximum extent. In terms of passive safety, the zero-run C01 adopts high-strength cage body, and the proportion of high-strength steel is as high as 73.9%. It is matched with the design of anti-collision beam of high-safety body and six SRS airbags/air curtains to construct all-round safety protection.

Breaking through the boundary of the scene to help users advance their life C.

Zero-run C01, with a strong C-position strength, is specially designed for the rational and upright enterprising school. They are not only the main responsibility of family responsibilities, but also the backbone of society; They enjoy the company of their families and pursue their personal love. At the same time, they also pursue success, keeping the power full and the computing power fully open at all times. And C01 is smart, warm and self-confident, which will undoubtedly become a brand-new connection point for its whole life scene and multi-circle communication. As Wu Baojun, co-founder and president of Zero Run Technology, said: "Zero Run C01 is the testimony of your achievements and the manifestation of the value of life, which will help you to continue to advance in life and reach the C position in life."

[Wu Baojun, co-founder, director and president of Zero Run Technology]

Focus on products, but also specialize in services. Zero-run cars strive to be sold without pressure, so that users can enjoy buying cars. At the same time, through courtesy services full of sense of ceremony and value, users’ joy at the delivery time can be amplified. In the future, Zero Run will provide door-to-door delivery services for car buyers in more than 70% cities across the country, and provide pick-up and delivery/scooter services for car buyers in more than 90% areas across the country, reducing users’ concerns about using cars.

0 yuan booked the C-seat courtesy, and the first owner enjoyed the lifetime warranty of Sandian.

Relying on the advantages of global self-research technology, C01 reshapes the value rules with the strength of hard-core products, and the pre-sale policy also subverts all routines and restrictions-all users who expect to achieve advanced life can enjoy the right of "0 yuan reservation" in C01. From the day of pre-sale release to the listing of C01, intended users can make reservations through the Zero Run Car APP, official website, WeChat applet or WeChat WeChat official account. The order of booking order is the order in which users get the same model and color car. At the same time, according to the policy announced on C01 listing date, you can enjoy the lifetime warranty rights of Sandian by signing a formal pre-sale contract. In order to ensure users’ rights and interests, the name of the licensed user shall not be changed in this order placed by 0 yuan, and it will be re-included in the order order if there is any change. 0 yuan’s decision not only gives users the right to choose freely, but also shows that Zero Run has enough confidence in product quality.

Adhere to the product strategy of "making luxury cars for the country", stick to the global self-research route, enter the growth period of results and value index with zero running, and the delivery volume continues to be advanced. This year, 30,666 users have joined the Zero Run family. In April, under the grim situation of frequent epidemics, chip shortage and rising raw material prices, the delivery volume of Zero Run was the smallest, with an overall delivery of 9,087 vehicles, winning the champion of the new car-making forces in one month and successfully advancing to the first camp of the new forces. The launch of C01 has further improved the product matrix of zero-run cars, and helped zero-run car brands to move up and enter the fast lane of development!?

Original fish visual sense

Four years ago, The Wandering Earth became a gift beyond the audience’s expectation, from a "small broken ball" that was not optimistic to a "China science fiction film benchmark".

Four years later, under the expectation of the audience, the China film market finally ushered in Wandering Earth 2.

Four years ago, the earth started a wandering journey to its new home in a crisis. Jason Wu played the match that Liu Pei strengthened his body and lit Jupiter, and used his life to protect the earth and mankind.

Four years later, the story started prequel, and Liu Peiqiang returned to his twenties. In the early days of the solar crisis, he was persistent, confused, powerful and fragile in conflicts and differences.

Four years ago, Jason Wu was a "special actor" in The Wandering Earth, with few scenes, and was finally written as "sacrifice" by the screenwriter.

Four years later, Jason Wu not only played opera, but also had tenderness for tough guys. Family and emotion have become the anchor points that China’s sci-fi movies can’t shake.

Shi Juezhi had an exclusive conversation with Jason Wu, talking about the film and the story behind it.

Jason Wu said that he was very surprised that China’s sci-fi movies had made such great progress in four years.

Friends who have walked into the cinema and watched the film can feel that Wandering Earth 2 is better than the last one:

The upgrade of special effects visible to the naked eye, the large-scale texture that comes from the face, and many grand scenes are shocking.

Speak with a set of data:

When The Wandering Earth had more than 2,000 special effects shots, it was regarded as a great challenge and surprise.

In Wandering Earth 2, there are more than 6,000 visual effects lenses. There are 102 sci-fi main scenes, and 17 studios have a landscape area of 58,000 square meters; 5,310 conceptual designs, 9,989 split-shot drawings, and more than 22,000 group performances at home and abroad …

It goes without saying that the film production cycle is long, the workload is heavy and the difficulty is high.

As a result, the big screen presents a picture of doomsday.

There is an amazing "space elevator", and the towering tower supported by several cables is full of science and technology.

Out-of-control drones flew into the sky and bombed the space elevator. The scene of the ark falling is very enjoyable.

There are also various natural disasters and space crises, and every scene is frightening.

Special effects, pictures and textures are upgraded in all directions, and thousands of special effects shots have completed this visual feast.

But the film can’t just be an empty shell of special effects, and the plot is the core of the film. Fortunately, Wandering Earth 2 is also doing well.

Jason Wu lamented: "Science fiction movies have to be directed by people like Frant Gwo. His macro perspective is so big that I really admire him."

The story of Wandering Earth 2 is set in the near future.

"At first, no one cared about this disaster, a mountain fire, the extinction of a species, until this disaster was closely related to everyone …"

The prologue shows the picture of the future, and mankind is encountering an unprecedented disaster-

The sun continues to expand. After 30 years, the sun will engulf the earth, and after 100 years, the solar system will no longer exist.

In order to save the fate of mankind, different factions have emerged on the earth.

For example, the "Digital Life Plan" allows human beings to achieve "mechanical soaring" through the growing artificial intelligence technology.

China people put forward the "plan to move mountains" (the predecessor of the "Wandering Earth Plan").

Since the earth is in crisis, it is better to "run away with the ball" directly, protect our homeland and leave a decent future for future generations.

The film began slowly in verifying the feasibility of various plans.

Director Frant Gwo’s control of the plot, and the seamless imagination details unconsciously make the audience feel that the future is close at hand.

The excellent performance of the actors is also a plus item.

For Jason Wu, the whole scene is as difficult as several scenes in space:

"How to imitate fighting in space and how to show weightlessness is a conceptual subversion. "

Jason Wu, who had three top martial arts scholars in his ancestors, never played imaginary games, and every scene was real.

In a fight with actor Wang Zhi, Jason Wu told her seriously: "You must really fight." Wang Zhi listened to the advice and filmed it many times. Only after calling it a day did he know that Jason Wu was injured and his thigh was bruised for many days.

The success of Wandering Earth 2 is the result of the joint efforts of all the cast members.

Gained a good score of 8.2 points on Douban, and many film critics also became tap water:

"The breakthrough of China’s film industrialization was unexpectedly realized by director Frant Gwo."

As early as after the The Wandering Earth craze faded, the audience calmed down, and the production team investigated the audience’s expectations for the sequel-

"I hope to see the progress of China science fiction movies. “

Simple words are a great challenge to The Wandering Earth series.

This time, Wandering Earth 2 returned to the big screen with all kinds of pressures and challenges, once again showing the charm and progress of China’s science fiction.

I have to say, the little broken ball did it again.

In the The Wandering Earth, Jason Wu played Liu Peiqiang in few scenes, and the scene of him crashing into Jupiter with the space station became a classic.

As a prequel to The Wandering Earth, Wandering Earth 2 unfolds the character’s experience, and makes Liu Peiqiang become an ordinary man with flesh and blood from a fearless lonely hero.

Talking about the role, Jason Wu told us: "Liu Peiqiang has a growing process in this play."

"He had rebellion, youth, decadence, love, master, family, husband, son-in-law and children of his own."

In the film, the audience follows Liu Peiqiang’s perspective and experiences all the ways of life under the arrival of the doomsday era.

At the beginning of the film, the young version of Liu Peiqiang walked with his master in the near-destroyed urban ruins. He had dark skin and sunglasses, and he had an enviable youthful atmosphere.

Later, I met a female soldier named Han Duoduo (played by Wang Zhi), and Liu Peiqiang was in love. Even though the world was gloomy, he still held red roses to express his romance.

When the villain occupied the space elevator and Liu Peiqiang broke into the secret room alone to outnumber the enemy, he said, "Even if I am alone, I will defend the space elevator to the death." Then began a wonderful fight.

At the end of the film, Liu Peiqiang, who grew a beard and became a lieutenant colonel, stayed in space day and night, touching the photos of his family. When he looked up at the vast universe outside the space capsule, his eyes were full of firmness and sadness.

As Jason Wu said: "Liu Peiqiang may suffer a lot of grievances and even grief in the end, but for the sake of his family, he will continue to work hard."

"Wandering Earth 2" gave Jason Wu plenty of room to play and launched Liu Peiqiang’s wonderful or bumpy first half of his life.

When we asked Jason Wu which of so many wonderful scenes was the most enjoyable, he chose the quietest farewell scene.

Liu Peiqiang participated in the astronaut selection only to give his family a chance to survive.

Liu Peiqiang, who is about to go to space, looked at his terminally ill wife lying in the hospital bed and her 4-year-old son, full of tears.

He held his wife’s hand and said softly, "I miss you", and she tried to answer him, "I have been there".

There is no presupposition and dialogue in this play, and it is entirely up to the free play of the actors. Jason Wu performed a man’s simplest love for his family and relatives.

After filming this scene, Jason Wu couldn’t be calm for a long time. The strongest tough guy at that moment also had a soft spot.

Many viewers were moved to tears by this scene. Jason Wu said: "This is an recognition of my performance, even more fulfilling than any play."

Wandering Earth 2 continues China people’s feelings of home and country.

Jason Wu and Andy Lau had a scene opposite each other. During the filming, they could not hear the sound through a thick glass plate, and Andy Lau could not be seen in Jason Wu’s room. However, only by relying on the details of their expressions, they performed the state of mind of the two people who are equally worried about their families despite their different identities.

The pattern of Wandering Earth 2 is not limited to this.

In the later stage of the film, it is planned to need 300 living people to detonate a nuclear bomb. In this mission with no return, the members of the China Space Team over 50 took the lead to take the initiative to step out and strive to be the fuse of the nuclear bomb, and Russia and other countries followed suit.

This belief and courage of human beings in the face of disasters makes people cry instantly.

The film expands its vision to the destiny of all mankind and becomes a truly globalist film-

This is not an old-fashioned personal heroic adventure story, but a grand epic of all mankind.

Under such a grand narrative, China’s sci-fi movies, with their unique romanticism, make the smallness and flash of human beings deeply hit people’s hearts again and again.

Wandering Earth 2 is not only a continuation of the previous work, but also a pioneering work, and it keeps moving forward on the road of creating hard-core science fiction in China.

This also makes people believe that in the most difficult time, there are always people who keep walking, and China science fiction movies have not been delayed.

With the popularity of the film, more and more details of the film have been "stripped" by netizens.

In such a doomsday sci-fi work, the production team was not delayed at all.

There used to be a famous food "dried aged earthworms" in The Wandering Earth, but now it takes 500,000 mosquitoes to make a "mosquito cake". At first glance, it is grandiose, but it is also reasonable, suggesting a shortage of resources in the future.

There are also patterns worn by little girl characters. In the real world, the rabbit pattern is a smiling face, but in the digital world, the rabbit pattern is a crying face, which makes people feel numb in an instant.

There are also many tributes hidden in the movie.

Some netizens think that the appearance of the original data of the Digital Life Plan pays tribute to the black stone tablet in 2001: A Space Odyssey, both of which have the mysterious meaning of the unknown world.

The film also pays tribute to Ng Man Tat through AI and CG synthesis technology. Times have changed, and people have never forgotten Uncle Da.

From the front to the back, this film has left many surprises for the audience, but Jason Wu said:

In fact, the story on the movie screen is very moving, and the story behind it is even more moving.

Jason Wu told us many behind-the-scenes stories, including the efforts of the cast members that were not noticed by the audience.

The most representative is director Frant Gwo, who strictly implemented the "5+4" life routine during the filming of Wandering Earth 2, that is, 5 cups of coffee and 4 hours of sleep every day, and pursued every detail.

After The Wandering Earth, many viewers were curious about how the earth started. Frant Gwo made a chronicle of nearly 200,000 words, connecting the beginning of the solar crisis, the departure of the earth and the crisis of Jupiter, so that the audience could understand the civilization and conflict in the film.

Until the trailer of Wandering Earth 2 was released, Frant Gwo was still not relieved. Someone on the Internet pointed out the design problem of the aircraft, and Frant Gwo directly replied: "Thank you, thank you, let’s change it quickly."

The same is true of actors.

Teacher Li Xuejian, who plays the representative of China, was ill before. His hearing was not good. Every time the crew worried about his health, Li Xuejian always said, "You don’t have to worry about me."

At the time of the deep winter festival, Li Xuejian filmed a scene of getting caught in the rain, and the water rushed over. Li Xuejian said, "Nothing, come again."

Jason Wu said frankly: "If you don’t visit the scene, you won’t feel the dedication of the older generation of actors."

Andy Lau, who is now 61 years old, not only has an understanding of drama, but also is adept at shooting all kinds of dramas.

Andy Lau’s last scene was filmed in the water almost all the time. He choked on water for real, just to make the details more real.

As Jason Wu said: "I know how hard it is to make a movie. He needs everyone to make their best efforts and have the greatest enthusiasm for movies to fulfill their dreams."

In the Spring Festival of 2023, Wandering Earth 2 only opened for 8 days, and it cracked 2.5 billion box office, which made people see the future and hope of China science fiction movies.

From this film, we can see not only the sincerity of the cast members, but also the ambition of China filmmakers to go global.

Just as Jason Wu and many filmmakers insisted, The Wandering Earth came into being, and The Wandering Earth series universe came into being.

The audience’s feelings are free. Maybe it can’t meet everyone’s expectations, but just like the sentence praised by 30,000 people on Douban:

"There is no need to compare anything. As a milestone, it is invincible."

Original title: Dialogue with Jason Wu: What happened to Wandering Earth 2 in 4 years? 》

Read the original text

As a top-class product for the future, it has not completely broken the current design idea, but evolved again on the basis of the existing design language. In terms of design, the overall design of MINI is classic, the whole front face looks dynamic, the headlights on both sides are sharp, and the internal light groups are patchwork, which makes it bright when lit. The sideways lines that rise sideways create a feeling of being ready to go, which looks very sporty. In addition, with the design of inch wheels, the sporty atmosphere is even stronger. At the same time, the reasonable proportion of luggage compartment cover and enclosure also gives the tail a lovely visual center of gravity, and the round taillight group of the new car is more eye-catching.

Coming to the interior of the whole vehicle, the design of the interior of MINI gives people the feeling of sports style. The steering wheel is made of leather and feels good. The leather package area of the center console is not small, and it feels soft. It is equipped with a 6.5-inch suspended large-size central control LCD screen, which has a clear display and a fashionable design. The front row is also equipped with a manual air conditioning control system to freely debug the most comfortable space atmosphere. At the same time, the new car also provides leather seats, which can bring certain comfort.

MINI has a length of 4008mm, a body width of 1727mm and a wheelbase of 2567mm, which is quite satisfactory. In the same class, the wheelbase of MINI ranks second. As a small car, its body size does not occupy much advantage in its class, and its internal seating space is only basically enough. After all, it is limited by the length and shape of the body. The five-door skylight of mini 2.0t Cooper’s obsessive version provides a wider view, which can create a better visual environment and good sensitivity for the rear passengers and increase the light entrance for the whole vehicle. In the same model with the same price, the trunk volume of MINI ranks third. The space is relatively regular, without obvious protrusions, and the overall loading capacity is good.

The MINI2.0T COOPER S obsessive five-door version uses a 2.0 engine with a maximum horsepower of 178 and a peak torque of 280, matching the wet dual clutch (DCT) gearbox. 2.0 The engine matched with the MINI is quite satisfactory in power performance, with weak low torque and can feel hysteresis. MINI’s official measured zero-acceleration score is 6.8S, ranking 4th among small car models with more than 800,000.

MINI’s active/passive safety configuration is complete, includingAutomatic parking、Zero tire pressure endurance tire、Automatic parking、Steep slope descent、hill start assist control、knee airbag、HUD head-up display、Anti-lock braking (ABS)、Braking force distribution (EBD/CBC, etc.)、Brake assist (EBA/BAS, etc.)、Traction control (ASR/TCS, etc.)、Active noise reduction、Engine start and stop、Side safety air curtain、Wireless charging of mobile phone、night vision system、LED daytime running lights、Forward reversing radar、Tire pressure monitoring、Steering wheel heating、Body stability control (ESP/DSC, etc.)、Rear reversing radar、Fatigue reminder、Remote parking、Child seat interface、Lane keeping (LKAS)Equal configuration.

Among them,Automatic parkingYou can avoid stepping on the brakes for a long time or needing to pull frequently;Steep slope descentCan safely pass through steep slope road conditions at low speed;knee airbagReduce the injury of the car interior to the occupant’s knees in the secondary collision.

In order to get a more comprehensive and objective understanding of MINI, you can go to the Easy Car MINI Forum and browse the messages of users who have bought the car in history.