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A group of multinational pharmaceutical companies, China’s revenue is open (attached list)

Source | Pharmacy (reproduced by Cybertron) Author | Medicine Circle Tao Ge At present, more than 10 multinational pharmaceutical companies have published 21-year financial reports. The author combed the revenue of multinational pharmaceutical companies in China market.　

According to the disclosure, the revenues of six multinational pharmaceutical companies in China are as follows: 77411644793299324

Source of data: financial report, vertical and horizontal arrangement of pharmaceutical affairs (billion US dollars)

AstraZeneca’s total revenue in 2021 was USD 37.417 billion (including COVID-19 vaccine), up 41% (38% CER) year-on-year; Total revenue excluding vaccines increased by 26% (CER was 23%) to $33.436 billion, and R&D expenditure was $9.736 billion, an increase of 36%. In the fourth quarter of 2021, the total revenue increased by 62% (63% of CER) to $12.011 billion. AZ expects that the total revenue growth in FY22 will be around 15%, and the core earnings per share will increase by 20%. In 2021, AstraZeneca achieved revenue of US$ 6.011 billion, up 12% year-on-year. China District is one of the important sources of AstraZeneca’s revenue. Due to the pressure of price reduction caused by medical insurance negotiation and centralized purchase, AstraZeneca’s growth in China slowed down in 2021 H2, and Q4′ s revenue decreased by 4% year on year. It is predicted that in 2022, the performance of China District may decline in single digits, mainly due to the continuous influence of centralized purchasing and medical insurance. 15381644793299474 　

Merck’s revenue in 2021 was US$ 48.704 billion, a year-on-year increase of 17%. Among them, the pharmaceutical business income was 42.754 billion US dollars, up 17% year-on-year; Animal health income was $5.568 billion, up 18% year-on-year. The revenue of K medicine was $17.2 billion, and the cervical cancer vaccine also contributed a lot to the revenue. In addition, the oral COVID-19 drug molnupiravir, which was urgently authorized for use in November last year, sold for 952 million US dollars in more than one month.

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Merck China has also become the best performing region in the world in 2021, with a total revenue of US$ 4.262 billion, up 60% year-on-year.

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Roche’s total revenue in 2021 was 62.801 billion Swiss francs (about 67.712 billion US dollars, according to the latest 1 Swiss franc = 10786 US dollars), up 9.3% year-on-year. Among them, the pharmaceutical business income was 45.041 billion Swiss francs, up 3.1% year-on-year, and the diagnostic business was 17.760 billion Swiss francs, up 29.5% year-on-year.

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China’s pharmaceutical business income in 2021 was 3.276 billion Swiss francs (US$ 3.533 billion), accounting for 7.3% of Roche’s global pharmaceutical business income, up 4% year-on-year; Diagnostic business income was 2.43 billion Swiss francs, up 22% year-on-year.

Tumor sector: Avastin (bevacizumab), Herceptin (trastuzumab) and Rituxan (rituximab), Roche’s "third troika", continue to suffer from the strong impact of biological similar drugs, and their income in 2021 decreased by 38%, 37% and 28% respectively, totaling only 7.749 billion Swiss francs.

Tecentriq(+24%%), kadcyla(+16%) and Alecensa(+18) maintained good growth, which was difficult to offset the decline of established products, and the overall tumor business income still declined by 11%.

5521644793299816

Sanofi’s net income in 2021 was 37.761 billion euros (US$ 43 billion), up by 7.1% year-on-year, including 26.970 billion euros (+7.6%) from pharmaceutical business, 6.323 billion euros (+6.8%) from vaccine business and 4.468 billion euros (+4.6%) from consumer health care business.

Sanofi’s pharmaceutical business mainly focuses on immune inflammation, nerves, rare diseases, tumors, and other fields. Dupixent is the core product of Sanofi at present. In 2021, the sales revenue increased by 52.7% year-on-year, and the sales reached 5.249 billion euros.

In June, 2020, it was approved to treat moderate and severe adult atopic dermatitis in China, and it was listed in the 2020 edition of the national medical insurance catalogue. In September, 2021, it was approved to expand the use of atopic dermatitis in adolescents over 12 years old in China.

74951644793299906

In 2021, China’s revenue was 2.72 billion euros (US$ 3.098 billion), up by 7.9% year-on-year, mainly due to the growth of Dupixent and the recovery of Plavix from the influence of volume procurement.

43671644793299962

Novartis’s net sales revenue in 2021 reached 51.626 billion US dollars, up 6% year-on-year. In 2021, the sales revenue of Novartis’ innovative drug sector was USD 42 billion, up by 8% year-on-year. At present, it is composed of Novartis Cancer and Novartis Pharmaceutical.

At present, the diseases covered by pharmaceutical business units mainly include immunization, blood diseases, skin diseases, ophthalmology, nerves, respiratory diseases, cardiovascular diseases, kidney and metabolic diseases and other mature diseases.

55851644793300013

In terms of specific varieties, Cosentyx (Scochizumab) and Entresto (Shakubatrivasartan), a new drug for heart failure, contributed a total of $8.266 billion last year, which is the core drug driving Novartis’ performance growth.

In 2021, the sales revenue in China market was USD 3.052 billion, up by 18% year-on-year, accounting for 6% of Novartis’ total global revenue.

Lilly’s total revenue in 2021 was $28.318 billion, a year-on-year increase of 15%; Among them, China’s revenue was US$ 1.661 billion, up 49% year-on-year, and China’s market revenue in 2020 was US$ 1.117 billion.

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Lilly’s current business mainly focuses on four major diseases: diabetes, tumor, immunity and nerve. The diabetes business has always been Lilly’s dominant and focused direction. Eight products, such as Trulicity (dulaglutide), Humulin (recombinant human insulin), Humalog (insulin lispro) and Jardiance (Engelje), generated revenue of $13.188 billion, accounting for 46.6% of the total revenue. Among them, the sales revenue of the fist product GLP-1 receptor agonist Trulicity reached 6.472 billion US dollars in 2021, and continued to maintain a steady and rapid growth of more than 20%.

References: financial reports of various companies; 1 Swiss franc = $1.0786; 1 Euro =1.1389 USD.

China’s medical technology and medical quality have improved significantly.

Standardized system, continuous improvement of quality supply, continuous increase of diagnosis and treatment services and accelerated optimization.
China’s medical technology and medical quality have improved significantly.

Recently, The Lancet, an international authoritative medical journal, published the latest ranking of global medical quality and accessibility. China’s HAQ (medical quality and accessibility) ranking has increased from the 60th in the world in 2015 to the 48th in 2016, and it is one of the most advanced countries in the medium SDI (socio-demographic index).

The ability of medical technology and the level of medical quality are directly related to the people’s sense of acquisition and are an important guarantee for people’s health. In recent years, the National Health and Wellness Committee has always regarded improving the medical technical ability and medical quality level as a key task, strengthened industry management and policy guarantee, and China’s medical technical ability and medical quality level have been continuously improved.

Institutionalization and standardization

Make medical care safer and more convenient.

"The Measures for the Management of Medical Quality promulgated and implemented in the form of departmental regulations provide institutional guarantee for the management of medical quality in China." A few days ago, Guo Yanhong, deputy director of the Medical Administration and Hospital Authority of the National Health and Wellness Committee, told the reporter that through continuous improvement of the medical quality management and clinical diagnosis and treatment related normative system, it has covered the clinical pathways of 1212 diseases in more than 30 majors and the clinical application management norms of key medical technologies.

Since the promulgation of China’s "Blood Donation Law" for 20 years, the rate of unpaid blood donation has continued to rise. In 2015, the central government funded the full coverage of blood nucleic acid testing nationwide, which greatly shortened the monitoring window period of blood-borne diseases such as AIDS and further improved the blood safety level.

It is understood that in 2017, China’s medical quality showed a trend of "four liters and one drop"-the supply of medical resources continued to increase, the efficiency of medical services improved, the quality of some specialties, key diseases and surgical diagnosis and treatment increased steadily, and the level of clinical rational drug use continued to improve, and the mortality rate of hospitalized patients continued to decline and stabilized at a low level.

According to the latest World Health Statistics 2018 released by the World Health Organization, China’s healthy life expectancy at birth exceeds that of the United States for the first time.

Moreover, in recent years, with the deepening of the "streamline administration, delegate power, strengthen regulation and improve services" reform, the supply-side structural reform in the field of medical services has been accelerated. By the end of 2017, there were 987,000 medical and health institutions in China, with 3.386 million doctors and 3.8 million nurses. With the steady growth of the registration number of medical institutions, doctors and nurses, the existing registration management model needs to be reformed urgently.

In order to promote the informatization construction of medical service management and practice supervision, National Health Commission initiated the reform of electronic registration management of medical institutions, doctors and nurses. Applicants for registration of medical institutions, doctors and nurses submit registration application materials to the health administrative department through the Internet, and the acceptance, review, certification, archiving and inquiry are all completed online.

The medical service informatization measures being promoted in various places have given patients more sense of gain. Taking Beijing as an example, municipal hospitals uniformly issue Beijing Medical Card for non-medical insurance patients, and patients can handle the whole process of medical services such as appointment registration with a Beijing Medical Card.

Specialized refinement

Make medical care more quality.

At 14: 00 on May 23rd, a message appeared on the WeChat platform of the multidisciplinary team of the Trauma Treatment Center of Peking University People’s Hospital: "Boy, 6 years old, car accident, traumatic subarachnoid hemorrhage, lung contusion, respiratory distress …" "Severe trauma first aid mechanism" was launched immediately, and relevant departments immediately entered the state of "preparing for war".

This is a 6-year-old boy from Cangzhou, Hebei Province, who was injured by a speeding motorcycle. The local hospital diagnosed him with severe multiple injuries and decided to transfer him to Peking University People’s Hospital for treatment. The 999 emergency center sent the children to Peking University People’s Hospital by aviation medical rescue helicopter. Multi-disciplinary expert emergency teams, such as trauma orthopedics, emergency department and neurosurgery, have already been waiting in the emergency room. The expert team will evaluate and consult the injury together and make a treatment plan. The Beijing-Hebei relay for life Tournament ended with the safe discharge of children.

The "closed-loop regional trauma treatment system with general hospitals as the core" led by Peking University People’s Hospital has effectively improved the treatment rate of patients with severe trauma. This innovative medical service model is benefiting more patients and is recognized as the "China model" for trauma treatment by peers at home and abroad.

"At present, China has produced a number of superior medical technologies that have reached or led the international advanced level and have a demonstration and driving role in the international arena, which has promoted the improvement of China’s ability to diagnose and treat major diseases." Guo Yanhong said that the ventricular assist device independently developed by Fuwai Hospital of China Academy of Medical Sciences has filled the technical gap in the field of ventricular assist research and development in China; The related research results of Renji Hospital of Shanghai Jiaotong University on gastrointestinal vascular diseases became the only basis for the relevant guidelines of the American Gastroenterology Association in 2015.

According to statistics, in 2017, China completed more than 16,000 organ transplants, accounting for 12.3% of the total organ transplants in the world in 2017, ranking second in the world. Quality indicators such as the survival rate of transplant recipients are also among the highest in the world.

The obvious improvement of medical institutions’ diagnosis and treatment ability is inseparable from the establishment and improvement of the national medical quality management and control system. At present, China has gradually improved the quality control organization system at the national, provincial and municipal levels. At the national level, 35 quality control centers have been established for disciplines such as anesthesia, pathology, clinical examination and nursing, and key diseases such as cardiovascular diseases, nervous system diseases and tumors. Provincial health administrative departments have also set up provincial quality control centers for related majors, and promoted the vertical extension of quality control organizations for key specialties such as hospital sensation and nursing to districts and counties.

Promoting continuous improvement of medical quality and safety through publicity

"Since 2015, we have organized and compiled the National Medical Service and Quality and Safety Report for three consecutive years, in which the 2015 and 2016 annual reports were released in the industry, and the 2017 annual report will be released to the whole society in the near future." Guo Yanhong introduced.

It is understood that the 2017 annual report covers the medical data of 107 million inpatients in nearly 7,000 medical institutions, and the data volume is 4.9 times higher than that in 2015 and 1.3 times higher than that in 2016. The number of inpatients sampled reached about 61% of inpatients in hospitals nationwide in 2016, which provided an important data base for scientifically and objectively reflecting the medical quality and safety situation in China.

Guo Yanhong said that the report comprehensively and objectively shows the current situation and status quo of medical services and quality and safety in China, and strengthens comparative analysis among regions, providing evidence-based basis for promoting the continuous improvement of medical services and quality and safety, as well as policy formulation and strengthening management.

"At present, there is still a certain gap between the ability and quality of medical technology in China and the growing health needs of the people; Due to the unbalanced economic and social development between regions, the differences in medical technology level and quality and safety between different regions still exist. " Guo Yanhong said that in the next step, the National Health and Health Commission will continue to take expanding the supply of high-quality medical resources, improving medical technology capabilities and promoting the continuous improvement of medical quality as its core tasks, increase counterpart support and assistance to provinces and provinces in the central and western regions, continuously improve the national medical quality management and control system, promote the wider application of modern medical technology in clinic, and continuously improve the scientific and refined level of medical quality and safety supervision. (Reporter Li Wanxiang)

General Administration of Customs： China’s import and export were flat in the first 11 months of this year, with a year-on-year increase of 1.2% in November.

　　CCTV News:According to the website of the General Administration of Customs, according to customs statistics, in the first 11 months of this year, China’s total import and export value was 37.96 trillion yuan, which was the same as that of the same period last year. Among them, exports reached 21.6 trillion yuan, up 0.3%; Imports were 16.36 trillion yuan, down 0.5%; The trade surplus was 5.24 trillion yuan, an increase of 2.8%. In dollar terms, in the first 11 months of this year, China’s total import and export value was 5.41 trillion US dollars, down 5.6%. Among them, exports were 3.08 trillion US dollars, down 5.2%; Imports were 2.33 trillion US dollars, down 6%; The trade surplus was $748.13 billion, narrowing by 2.7%.

　　In November this year, China’s import and export amounted to 3.7 trillion yuan, an increase of 1.2%. Among them, exports were 2.1 trillion yuan, up by 1.7%; Imports reached 1.6 trillion yuan, up by 0.6%; The trade surplus was 490.82 billion yuan, an increase of 5.5%. In dollar terms, in November this year, China’s import and export amounted to 515.47 billion US dollars, the same as last year. Among them, exports reached 291.93 billion US dollars, up by 0.5%; Imports reached US$ 223.54 billion, down 0.6%; The trade surplus was $68.39 billion, an increase of 4%.

　　Main features of China’s import and export in the first 11 months of this year:

　　The import and export of general trade increased and its proportion increased. In the first 11 months, China’s general trade import and export was 24.58 trillion yuan, up 1.6%, accounting for 64.8% of China’s total foreign trade, up 1 percentage point over the same period last year. Among them, the export was 13.94 trillion yuan, an increase of 2%; Imports reached 10.64 trillion yuan, up by 1%. In the same period, the import and export of processing trade was 6.97 trillion yuan, down 9.7%, accounting for 18.4%. Among them, exports were 4.5 trillion yuan, down 8.6%; Imports were 2.47 trillion yuan, down 11.6%. In addition, China’s import and export by bonded logistics was 4.99 trillion yuan, an increase of 6.6%. Among them, exports were 1.98 trillion yuan, an increase of 10.3%; Imports reached 3.01 trillion yuan, up 4.3%.

　　Imports and exports to ASEAN increased, and imports from the EU increased. In the first 11 months, ASEAN was my largest trading partner, and the total trade value between China and ASEAN was 5.8 trillion yuan, up by 0.1%, accounting for 15.3% of China’s total foreign trade. Among them, exports to ASEAN were 3.33 trillion yuan, down 0.1%; Imports from ASEAN reached 2.47 trillion yuan, up by 0.4%; The trade surplus with ASEAN was 850.06 billion yuan, narrowing by 1.7%. The EU is my second largest trading partner, and my total trade with the EU is 5.03 trillion yuan, down 2.2%, accounting for 13.2%. Among them, exports to the EU were 3.22 trillion yuan, down 5.8%; Imports from the EU reached 1.81 trillion yuan, an increase of 5%; The trade surplus with the EU was 1.41 trillion yuan, narrowing by 16.7%. The United States is my third largest trading partner, and my total trade with the United States is 4.26 trillion yuan, down 6.9%, accounting for 11.2%. Among them, exports to the United States were 3.21 trillion yuan, down 8.5%; Imports from the United States were 1.05 trillion yuan, down 1.6%; The trade surplus with the United States was 2.16 trillion yuan, narrowing by 11.6%. Japan is my fourth largest trading partner, and my total trade with Japan is 2.04 trillion yuan, down 6.2%, accounting for 5.4%. Among them, exports to Japan were 1.01 trillion yuan, down 3.3%; Imports from Japan were 1.03 trillion yuan, down 8.8%; The trade deficit with Japan was 10.97 billion yuan, narrowing by 85.4%. In the same period, China has jointly built the "Belt and Road"The country’s total import and export was 17.65 trillion yuan, an increase of 2.6%. Among them, exports were 9.7 trillion yuan, an increase of 6.9%; Imports reached 7.95 trillion yuan, down 2.1%.

　　The import and export of private enterprises maintained growth. In the first 11 months, the import and export of private enterprises was 20.24 trillion yuan, up 6.1%, accounting for 53.3% of China’s total foreign trade, up 3.1 percentage points over the same period last year. Among them, exports were 13.62 trillion yuan, up 5.3%, accounting for 63% of the total export value; Imports were 6.62 trillion yuan, up 7.6%, accounting for 40.5% of the total import value. The import and export of state-owned enterprises was 6.08 trillion yuan, down 0.8%, accounting for 16% of China’s total foreign trade. Among them, exports were 1.72 trillion yuan, an increase of 0.4%; Imports were 4.36 trillion yuan, down 1.2%. In the same period, the import and export of foreign-invested enterprises was 11.54 trillion yuan, down 9%, accounting for 30.4% of China’s total foreign trade. Among them, exports were 6.23 trillion yuan, down 9.3%; Imports reached 5.31 trillion yuan, down 8.7%.

　　Mechanical and electrical products accounted for nearly 60% of exports, including mobile phones and automobiles. In the first eleven months, China exported 12.66 trillion yuan of mechanical and electrical products, an increase of 2.8%, accounting for 58.6% of the total export value. Among them, automatic data processing equipment and its parts and components were 1.2 trillion yuan, down 17.2%; Mobile phones reached 885.25 billion yuan, up by 3.3%; Automobile was 652.92 billion yuan, an increase of 79.6%. In the same period, the export of labor products was 3.73 trillion yuan, down 2.6%, accounting for 17.3%. Among them, clothing and clothing accessories were 1.02 trillion yuan, down 3.3%; Textiles reached 865.57 billion yuan, down 3.7%; Plastic products reached 639.13 billion yuan, up 0.5%. The export of agricultural products was 628.65 billion yuan, up by 6.6%.

　　Imports of major commodities such as iron ore, crude oil, coal, natural gas and soybeans increased. In the first 11 months, China imported 1.078 billion tons of iron ore, up 6.2%, and the average import price (the same below) was 788.8 yuan per ton, up 2.3%. 516 million tons of crude oil, an increase of 12.1%, 4192 yuan per ton, down 13.1%; 427 million tons of coal, up 62.8%, 785.1 yuan per ton, down 19.6%; 107 million tons of natural gas, up 8.5%, 3,715 yuan per ton, down 11.4%; 89.625 million tons of soybeans, up by 13.3% and 4,237.3 yuan per ton, down by 5.1%; Refined oil was 43.225 million tons, up by 86.6% and 4,123.7 yuan per ton, down by 18.8%. In addition, 26.995 million tons of plastics with primary shapes were imported, down by 3.7% to 10,800 yuan per ton, down by 12.5%; The unwrought copper and copper products reached 5.042 million tons, a decrease of 5.9% and 61,000 yuan per ton, a decrease of 1.1%. In the same period, the import of mechanical and electrical products was 5.91 trillion yuan, down 6.5%.

More than 200 riders who have been selected as ＂good walkers＂ for six consecutive years have been commended.

　 　 　 　China Economic News Network (Reporter Li Xiaohong)In recent years, with the continuous growth of flexible employment groups, as "city ferrymen" who maintain people’s convenient life, flash couriers and courier brothers have frequently reported cases of participating in unexpected rescue. With large scale and strong mobility, riders often appear in the first scene of all kinds of emergencies, and have become a social love and rescue force that cannot be ignored.

　 　 　 　As a representative platform of the instant delivery industry in the same city, flash delivery has long advocated the service concept of "delivering with kindness" among riders. In order to encourage flash drivers to do good deeds and be good people, from 2019, flash delivery will start the selection of "good walkers", and 10-mdash will be selected every quarter; 20 riders who do mortal charity. At present, more than 200 riders have been commended.

　 　 　 　Zhang Ben, a Beijing flash worker who was once rated as "Top Ten Most Beautiful Ambulancemen in 2022", is one of them. On August 11, 2022, Zhang Ben met a passer-by who fell to the ground in a coma during the delivery. He participated in the Red Cross first aid training organized by the flash delivery organization and passed the examination. He used the first aid knowledge he learned to win life time for the injured. There are still many people like him in the team of flash drivers: Jin Shifu rescues comatose car owners, Master Gao rescues pregnant women who have fallen, and Master Wan uses first aid knowledge to help the injured regain consciousness … … Many knights incarnate as "mobile ambulance stations" on the highway. These ordinary kindness have not been ignored. They are timely rain for those in distress, and they are even more "good walkers" who flash the official certification.

Picture 13

　 　 　 　Recently, the list of "good walkers" in the second quarter of 2024 was officially released. Master Wan from Beijing, Master Liang from Liuzhou in Guangxi, Master Ye from Ganzhou in Jiangxi, Master Gao from Yuncheng in Shanxi, Master Meng from Wuxi in Jiangsu, Master Yu from Ningbo in Zhejiang, Master He from Beijing, Master Ye from Qingyuan in Guangdong, Master Yang from Ningbo in Zhejiang and Master Yang from Haikou in Hainan won this honor. The spirit of helping others and doing good deeds are forming a powerful force, affecting more and more riders.

　 　 　 　In order to encourage more people to join the ranks of transmitting goodwill, since the first quarter of 2024, Flash Delivery has expanded the selection scope of "good doers". In addition to 10 "national good doers", 10 "urban good doers" are selected every quarter, which also transmits the power of kindness in the ordinary.

　 　 　 　In addition, Flash has set up a special care and protection team for riders, striving to build a symbiotic and win-win ecology with riders. In addition to the selection of "good walkers", "Rider Promotion Plan", "College Entrance Examination Assistance Plan" and "Knight’s Home" … … "Kindness and altruism" is not only the cultural spirit that has been promoted to riders for a long time, but also the humanistic care that the platform practices and promotes with actions.

　 　 　 　In the future, Flash will launch more rider care service initiatives and love reward mechanisms, and continue to empower the "mortal charity" of the flash workers.

Langfang BMW i4 price reduction information! The lowest price is 328,900, so act quickly.

[car home Langfang Preferential Promotion Channel] At present, a large-scale preferential activity is being launched in Langfang area, and the maximum preferential amount has reached an astonishing 165,000 yuan, which has reduced its minimum starting price to 328,900 yuan. If you are interested in this model and want to get more discounts, please click the "Check Car Price" button in the quotation form.

廊坊宝马i4降价信息！最低售价32.89万，赶快行动

The BMW i4 has a stylish and scientific design, and the front face adopts the iconic kidney-shaped air intake grille. Although it adopts a closed design, it incorporates blue decorative strips inside to show its identity as an electric vehicle. On both sides of the grille are sharp LED headlights, which combine with daytime running lights to create a strong visual impact. On the whole, the body lines of BMW i4 are smooth and sporty, showing a modern and elegant style.

BMW i4 has a length, width and height of 4785*1852*1455 mm and a wheelbase of 2856 mm, which gives the vehicle spacious and comfortable interior space. Its side lines are smooth, and the distance from the front wheel to the rear wheel is 1601 mm and 1630 mm respectively, creating a dynamic visual effect. The front tyre size is 245/45 R18, and the rear tyre size is 255/45 R18. With the unique rim design, the overall shape is more exquisite and sporty.

廊坊宝马i4降价信息！最低售价32.89万，赶快行动

The interior design of BMW i4 shows the perfect combination of luxury and technology, and the overall style is simple and modern. Equipped with a 14.9-inch central control screen, the operation is smooth and the information display is clear, which supports the voice recognition control of multimedia system, navigation, telephone and air conditioner, greatly improving the driving experience. The steering wheel is made of leather, which feels comfortable and supports manual adjustment up and down and back and forth, providing drivers with a high degree of personalized adjustment space. The car is also equipped with two USB and Type-C interfaces, which is convenient for passengers to charge the equipment at any time. The front seats provide heating function, and the driver’s seat has electric memory function. Both the front and rear seats can be adjusted in various ways, including front and rear adjustment, backrest adjustment, height adjustment (4-way), leg rest adjustment and lumbar support (4-way), which ensures the comfort of drivers and passengers. The seat material of BMW i4 is rich and varied, including imitation leather, genuine leather and fabric/suede mix, which is not only beautiful but also durable. In addition, the car also provides a mobile phone wireless charging function, which adds convenience to modern life.

廊坊宝马i4降价信息！最低售价32.89万，赶快行动

The BMW i4 is equipped with a high-performance motor, which can output a maximum power of 250kW and a maximum torque of 430Nm, providing strong power performance for the vehicle.

The owner of car home said that the configuration parameters of Series I 3, 5 and X3 are almost the same, but the shell is different. Even if you spend more than 100,000 yuan willfully, you should choose BMW i4, because what he pursues is its unique face value and personality. In addition, he also stressed that the BMW i4 is an imported model, and there is no need to change the logo after purchase. The design of big nostril can make people see its extraordinary at a glance, and some people even mistakenly think that its price is as high as 600 thousand, which makes him feel proud and a little embarrassed.

A-shares bottomed out, has the market stopped falling and stabilized？

A shares bottomed out and rebounded.

On January 23, the three major indexes of the market opened lower and went higher, and rebounded across the board. After rising rapidly in the afternoon, the increase was further expanded. Among them, the Shenzhen Stock Exchange Index and the Growth Enterprise Market Index both rose more than 1.2%.

Regarding the rebound of the market on Tuesday, the chief strategist of a securities firm told The Paper: "There was no obvious direct negative in the market before, and the adjustment was more driven by emotions. Under the influence of good news, the market sentiment has also eased. "

"For the current market position, I still think that it should have bottomed out in the short term. There is little market risk before the Spring Festival. Recently, I added some funds." The chief strategist of the brokerage firm said with a smile.

The chief investment officer of a brokerage firm in Shanghai also told the The Paper reporter: "It should be said that the current position is completely pessimistic, and there is a bigger rebound below this position. The faster it falls, the faster it will rebound."

Technically, zhaowei, an analyst at Founder Securities, analyzed in the research report on January 23rd that there is still a rebound demand in the short-term market, which is expected to challenge the pressure on the 5th line technically. Among them, whether it can challenge and cross the 5-day line and whether the quantity can be released is the key.

Bottom rebound

According to Great Wisdom VIP, as of the close of January 23rd, the Shanghai Composite Index rose 0.53% to 2,770.98 points; The Science and Technology Innovation 50 Index rose 1.01% to 749.74 points; The Shenzhen Component Index rose 1.38% to 8596.28 points; The growth enterprise market index rose 1.24% to 1687.61 points.

On the disk, after several consecutive days of shocks, A shares in the sector ushered in a long-lost general increase. Under the first-class industry classification of Shenwan, 27 of the 31 sub-sectors are floating red, and only banks, commercial retail, food and beverage and textile and apparel have fallen slightly.

Among them, the media sector surged more than 3.5% throughout the day, the coal and computer sectors rose more than 2%, and communications, non-bank finance, real estate and national defense industries all rose more than 1%.

"On the whole, the quantity can shrink but the structural differentiation has decreased. Big tickets are stronger than small tickets, and blue chips are stronger than growth. Risk appetite increased slightly and market confidence was boosted, which was the main feature of Tuesday (January 23). " Zhaowei said.

For the rebound of the market, many interviewees mentioned the positive impact of the news in the capital market.

"The NPC attaches great importance to the capital market, and the market speculates that there may be some new policies on the capital market, which will boost the market sentiment." The chief investment officer of the above brokerage said.

Zhaowei also pointed out that the regular meeting of the National People’s Congress indicated that more powerful and effective measures should be taken to stabilize the market and confidence, and it was announced that the medium and long-term capital would enter the market in the next step. This is undoubtedly a heavy positive signal in the recent depressed capital market, which means that a powerful rescue policy will be introduced soon. Under the influence of positive news, the market bottomed out on Tuesday.

On January 22nd, Premier Li Qiang of the State Council presided over the the State Council executive meeting to listen to the report on the operation of the capital market and work considerations. The meeting stressed that it is necessary to further improve the basic system of the capital market, pay more attention to the dynamic balance of investment and financing, vigorously improve the quality and investment value of listed companies, increase the medium and long-term capital entering the market, and enhance the internal stability of the market. We should take more effective measures to stabilize the market and confidence.

On January 23rd, Yi Huiman, Secretary of the Party Committee and Chairman of the CSRC, presided over the (enlarged) meeting of the Party Committee. The meeting stressed that efforts should be made to maintain the stable operation of the capital market. We will persist in striving for stability and promoting stability through progress, put the stable operation of the capital market in a more prominent position, and strive to stabilize the market and stabilize confidence. Vigorously improve the quality and investment value of listed companies, and build a valuation system of listed companies with China characteristics. Deepen the reform of the investment side, increase the intensity of medium and long-term capital entering the market, promote the dynamic balance of investment and financing, and continuously enhance the internal stability of the stock market.

Keep a positive attitude, there is still a rebound requirement on the technical side.

As the market rebounds, what will A shares do next?

"In the short term, the current mood of the market has reached the bottom, and the current position is extremely cost-effective. Therefore, there is no need to be pessimistic in this position in the market. " The chief investment officer of the aforementioned brokerage firm said.

Zhaowei also pointed out that although the rebound of the market on Tuesday (January 23rd) was still insufficient, it was because the pressure around 2863 was still relatively high, which required a time-space transformation process. At present, the market’s common expectation of confidence return route has gradually become clear, and the market has never fallen for more than five consecutive quarters. Next, investors can keep a positive attitude and wait for the introduction of policy tools for the current market.

Technically, zhaowei said that after the market opened lower on Tuesday (January 23), it fluctuated sharply around the previous closing point, gradually rose in the afternoon, and closed in red, showing a trend of price increase and volume decrease. All the moving averages were arranged short, and the volume and price of price increase and volume decrease deviated from the trend, and it will be repeated in short-term intraday trading.

"However, the market still deviates from the 5-day trend, which is technically oversold. In addition, the SKD indicator of the daily line continues to deviate from the bottom three times, and there is still a rebound requirement in the short-term session. Whether the 5-day line can be broken and whether the quantity can be released is the key. At the same time, the technical indicators of the time-sharing chart show that the 15-minute MACD indicator continues to strengthen, the 30-minute MACD indicator is golden, and there are rebound requirements in the short-term session. " Zhaowei pointed out.

Zhaowei further pointed out that, on the whole, there is still a demand for rebound in the short-term market, which is technically expected to challenge the pressure on the 5th line. Whether it can challenge and cross the 5th line and whether the quantity can be released is the key. If the quantity can be released again, 2724 points will be the stage low regardless of the ups and downs; If the quantity can be released effectively, 2724 points can not be confirmed as the stage low regardless of the ups and downs.

"At present, the point is low enough, and stabilization is something that can happen at any time." Another brokerage investment Gu said that there are three signals for the market to stop falling and stabilize. First, the form must be out of the reverse form, and it is the most basic condition to create a physical heavy-duty zhongyang line to reverse the heavy-duty zhongyin on Monday. Second, the market sentiment must be reversed. We can observe whether the position of the yellow and white lines is switched at the same time when the yellow and white lines are rising together on the time-sharing chart, and whether the yellow line is running above the white line (the increase of individual stocks exceeds the index). The third is to see if there is a leading sector with strong market influence, which can not only drive the index but also drive the market popularity. For example, brokers known as bull market engines are easy to activate the market and activate the Shanghai Composite Index once they start at a low level.

In terms of allocation, zhaowei suggested that investors should watch more and move less in operation, those who are light positions should wait and see, those who are heavy positions should adjust their position structure, pay attention to new energy sources and brokers on dips, and avoid junk stocks and stocks with high share prices that are at risk of making up for losses.

2.0T+ wet dual clutch (DCT) is finally on fire!

As a top-class product for the future, it has not completely broken the current design idea, but evolved again on the basis of the existing design language. In terms of design, the overall design of MINI is classic, the whole front face looks dynamic, the headlights on both sides are sharp, and the internal light groups are patchwork, which makes it bright when lit. The sideways lines that rise sideways create a feeling of being ready to go, which looks very sporty. In addition, with the design of inch wheels, the sporty atmosphere is even stronger. At the same time, the reasonable proportion of luggage compartment cover and enclosure also gives the tail a lovely visual center of gravity, and the round taillight group of the new car is more eye-catching.

Coming to the interior of the whole vehicle, the design of the interior of MINI gives people the feeling of sports style. The steering wheel is made of leather and feels good. The leather package area of the center console is not small, and it feels soft. It is equipped with a 6.5-inch suspended large-size central control LCD screen, which has a clear display and a fashionable design. The front row is also equipped with a manual air conditioning control system to freely debug the most comfortable space atmosphere. At the same time, the new car also provides leather seats, which can bring certain comfort.

MINI has a length of 4008mm, a body width of 1727mm and a wheelbase of 2567mm, which is quite satisfactory. In the same class, the wheelbase of MINI ranks second. As a small car, its body size does not occupy much advantage in its class, and its internal seating space is only basically enough. After all, it is limited by the length and shape of the body. The five-door skylight of mini 2.0t Cooper’s obsessive version provides a wider view, which can create a better visual environment and good sensitivity for the rear passengers and increase the light entrance for the whole vehicle. In the same model with the same price, the trunk volume of MINI ranks third. The space is relatively regular, without obvious protrusions, and the overall loading capacity is good.

The MINI2.0T COOPER S obsessive five-door version uses a 2.0 engine with a maximum horsepower of 178 and a peak torque of 280, matching the wet dual clutch (DCT) gearbox. 2.0 The engine matched with the MINI is quite satisfactory in power performance, with weak low torque and can feel hysteresis. MINI’s official measured zero-acceleration score is 6.8S, ranking 4th among small car models with more than 800,000.

MINI’s active/passive safety configuration is complete, includingAutomatic parking、Zero tire pressure endurance tire、Automatic parking、Steep slope descent、hill start assist control、knee airbag、HUD head-up display、Anti-lock braking (ABS)、Braking force distribution (EBD/CBC, etc.)、Brake assist (EBA/BAS, etc.)、Traction control (ASR/TCS, etc.)、Active noise reduction、Engine start and stop、Side safety air curtain、Wireless charging of mobile phone、night vision system、LED daytime running lights、Forward reversing radar、Tire pressure monitoring、Steering wheel heating、Body stability control (ESP/DSC, etc.)、Rear reversing radar、Fatigue reminder、Remote parking、Child seat interface、Lane keeping (LKAS)Equal configuration.

Among them,Automatic parkingYou can avoid stepping on the brakes for a long time or needing to pull frequently;Steep slope descentCan safely pass through steep slope road conditions at low speed;knee airbagReduce the injury of the car interior to the occupant’s knees in the secondary collision.

In order to get a more comprehensive and objective understanding of MINI, you can go to the Easy Car MINI Forum and browse the messages of users who have bought the car in history.

[Provincial Market Supervision Bureau] Shaanxi standardizes the marketing behavior of takeaway merchants to prevent food waste

Our province will urge online catering platforms to optimize marketing rules and agreement rules, publish appropriate order consumption reminders in prominent positions on the relevant APP and Mini Program’s meal display, order submission, order completion pages, etc., reasonably determine the minimum price of meals, and optimize the price-break discounts collection mechanism; guide online catering platforms to embed standards related to the prevention of catering waste into all aspects of platform operation, establish and improve the catering waste self-inspection system and consumer information feedback mechanism, and promptly correct non-standard marketing behaviors; urge catering takeaway merchants to formulate and improve marketing norms, strengthen dynamic management of food procurement, storage, processing, and meal supply, and supervise their standardized marketing behaviors. Consumers must not be induced or misled to order too much; actively promote food safety sealing and reduce distribution Catering waste caused by pollution, damage, etc. during the process.

Our province will also increase the supervision of anti-food waste, combine daily supervision and inspection of food safety with the prevention of food waste, and carry out it simultaneously. Adhere to the combination of online and offline, and focus on checking whether platforms and merchants have prompts to remind them that their responsibilities are not implemented, induce consumers to order too much, and whether there is serious food waste in offline business places. Strengthen administrative guidance for illegal platforms and merchants. Continue to carry out "random restaurant inspection" activities, conduct random inspections on merchants’ implementation of the food waste prevention system, and check the implementation of "small dishes", "half dishes" and meal portions.

"We will also urge catering companies to incorporate the prevention of food waste into the food safety’daily control, weekly investigation and monthly dispatch ‘system, and strengthen self-inspection and self-correction. At the same time, in accordance with the principle of both corrections and equal penalties, we will correct violations of laws and regulations such as inducing excessive orders in accordance with laws and regulations," said She Dayong, director of the food business safety supervision and management department of the provincial market supervision bureau.(Reporter: Xu Ying)

Deng Chao’s Spring Festival Gala stage jumped with excitement, netizens： Hope to change the reserved program

Deng Chao

Deng Chao

　　　　 The 2023 CCTV Spring Festival Gala for the Year of the Rabbit is underway. Deng Chao, who has always been full of vitality, is still in high spirits. On the stage of the song "Good Luck All Comes", he not only brought cheerful singing and an excited atmosphere to the audience, but also offered an excited leap. Eagle-eyed netizens began to speculate: "Deng Chao can’t be covering up and forgetting to take a position!"

　　In addition to joking, netizens were also infected by Deng Chao’s hard-working performance, and many couldn’t help but want to turn Deng Chao’s singing and dancing show into another "Unforgettable Tonight" and become a reserved program for the Spring Festival Gala. "He really fits the atmosphere of the Spring Festival Gala, hahaha!" It has to be said that it is the brother Chao who always excitedly "jumps high" on the stage of the Spring Festival Gala!

　　(Han/Chinese)

Such as knife cutting, fire! This disease is ＂painful＂ and hot search. Do you want to fight thousands of dollars of vaccine？

focus

Recently, a # Pain is a danger signal of herpes zoster # boarded a hot search in Weibo, causing everyone’s attention to herpes zoster!

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How painful is it to get herpes zoster? People who have had this disease are worried about it and complain bitterly!

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What disease is herpes zoster?

Herpes zoster is what people call "raw snake", "waist-wrapped dragon" and "waist-turned dragon", which is infected by varicella-zoster virus and occurs in middle-aged and elderly people over 50 years old, showing clustered blisters.

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At the time of eruption, the skin of the affected area first appeared tidal erythema, then appeared clustered papules without fusion, and then quickly turned into blisters, with redness around the blisters. Skin lesions are often distributed along a certain peripheral nerve area, generally occurring on one side of the body and not exceeding the midline. Blisters will then dry up, scab and fall off, and there may be pigmentation left behind. Generally, skin lesions last for 2-3 weeks, and the elderly are about 3-4 weeks.

Characteristics of herpes zoster-high infection rate.

According to public information, herpes zoster is more common in older people with immunosuppression or immunodeficiency. According to Professor Chang Jianmin, director of the dermatology department of Peking Hospital and deputy director of the Department of Dermatology and Venereology of Peking University, in China, about 99.5% of adults aged 50 and above are latent varicella-zoster virus, and there are about 1.56 million new cases of herpes zoster in people aged 50 and above every year. According to the China Expert Consensus on Diagnosis and Treatment of Postherpetic Neuralgia, the annual incidence of herpes zoster is about 3-5‰.

Characteristics of herpes zoster-patients have to bear great pain.

It is understood that the onset of herpes zoster is very painful, such as cutting, burning, electric shock and whipping. The degree of pain is higher than that of childbirth, and even some patients will suffer from inattention, disorder, anxiety and depression, which is both physical and psychological. Some netizens commented: "Once you get sick, it invades your nerves and hurts like hell."

Often accompanied by significant neuralgia.

There is a saying: "snake sores, waist-wrapped dragons, crawling all over the circle will kill people", which means that it is painful when it comes on. It affects work during the day and sleep at night. Herpes zoster is contagious, mainly through droplets and contact.

Recently, with the increase of rain and the arrival of humid weather, the resistance of middle-aged and elderly people is extremely easy to decline, and herpes zoster is also prone to high incidence. Everyone must pay attention to it.

Vaccination can effectively prevent

Herpes zoster vaccine, namely recombinant herpes zoster vaccine (CHO cell), was officially launched in China in early July 2020. It is suitable for preventing herpes zoster. The vaccination target is adults aged 50 and over, and the immunization program is 2 doses.

Vaccination interval is 2 months, and the longest is no more than 6 months. Experts say that herpes zoster is a common disease in the elderly. To prevent the occurrence of herpes zoster, the first is to improve immunity, and the second is very important for middle-aged and elderly people to get a rash vaccine!

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For friends over 50 years old, it is recommended to vaccinate against herpes zoster, because with the increase of age, the probability of herpes zoster is getting higher and higher, and the incidence rate of people over 50 years old is obvious because of the gradual decline of cellular immune function, and active vaccination can reduce this risk. Vaccination is more recommended for people over 50 years old who have had chickenpox and their immunity is relatively low.

Do people who have had it still need to be vaccinated?

Experts say that people who have had herpes zoster once have a very low chance of getting sick again. The human body has a memory of herpes zoster virus immunity and will produce antibodies to avoid getting sick again.

However, people who have had herpes zoster and have relapsed still exist. Such patients often have very low immunity. After getting herpes zoster for the first time, they did not get enough antibodies. Therefore, when a similar situation occurs for the second time, the antibodies in the body are not enough to resist the virus, which will make the disease happen again. Therefore, for patients who have experienced herpes zoster recurrence, experts still recommend vaccination against herpes zoster to prevent recurrence.

Domestic listing enters countdown.

Throughout the world, there are two kinds of herpes zoster vaccines listed. Among them, shingrix from GlaxoSmithKline was approved to be listed in China in 2019 for preventing herpes zoster in adults aged 50 and over, and was officially launched in China market on June 28th, 2020, which is the only herpes zoster vaccine listed in China at present.

As herpes zoster vaccine belongs to the national immunization program, patients need to pay for it themselves. The price announced by Shanghai CDC is 1603.5 yuan/dose, and the full vaccination price is 3207 yuan, which is also the general price of community centers around the world, and the vaccination fee is not cheap. It is worth noting that at present, many domestic pharmaceutical companies are researching and developing the distribution of herpes zoster vaccine, and the fastest research and development company has received the Acceptance Notice of the application for the marketing license of live attenuated herpes zoster vaccine issued by the Drug Evaluation Center of China Food and Drug Administration. In other words, the vaccine has entered the stage of applying for marketing!

Source of this article: CCTV