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Such as knife cutting, fire! This disease is ＂painful＂ and hot search. Do you want to fight thousands of dollars of vaccine？

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Recently, a # Pain is a danger signal of herpes zoster # boarded a hot search in Weibo, causing everyone’s attention to herpes zoster!

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How painful is it to get herpes zoster? People who have had this disease are worried about it and complain bitterly!

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What disease is herpes zoster?

Herpes zoster is what people call "raw snake", "waist-wrapped dragon" and "waist-turned dragon", which is infected by varicella-zoster virus and occurs in middle-aged and elderly people over 50 years old, showing clustered blisters.

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At the time of eruption, the skin of the affected area first appeared tidal erythema, then appeared clustered papules without fusion, and then quickly turned into blisters, with redness around the blisters. Skin lesions are often distributed along a certain peripheral nerve area, generally occurring on one side of the body and not exceeding the midline. Blisters will then dry up, scab and fall off, and there may be pigmentation left behind. Generally, skin lesions last for 2-3 weeks, and the elderly are about 3-4 weeks.

Characteristics of herpes zoster-high infection rate.

According to public information, herpes zoster is more common in older people with immunosuppression or immunodeficiency. According to Professor Chang Jianmin, director of the dermatology department of Peking Hospital and deputy director of the Department of Dermatology and Venereology of Peking University, in China, about 99.5% of adults aged 50 and above are latent varicella-zoster virus, and there are about 1.56 million new cases of herpes zoster in people aged 50 and above every year. According to the China Expert Consensus on Diagnosis and Treatment of Postherpetic Neuralgia, the annual incidence of herpes zoster is about 3-5‰.

Characteristics of herpes zoster-patients have to bear great pain.

It is understood that the onset of herpes zoster is very painful, such as cutting, burning, electric shock and whipping. The degree of pain is higher than that of childbirth, and even some patients will suffer from inattention, disorder, anxiety and depression, which is both physical and psychological. Some netizens commented: "Once you get sick, it invades your nerves and hurts like hell."

Often accompanied by significant neuralgia.

There is a saying: "snake sores, waist-wrapped dragons, crawling all over the circle will kill people", which means that it is painful when it comes on. It affects work during the day and sleep at night. Herpes zoster is contagious, mainly through droplets and contact.

Recently, with the increase of rain and the arrival of humid weather, the resistance of middle-aged and elderly people is extremely easy to decline, and herpes zoster is also prone to high incidence. Everyone must pay attention to it.

Vaccination can effectively prevent

Herpes zoster vaccine, namely recombinant herpes zoster vaccine (CHO cell), was officially launched in China in early July 2020. It is suitable for preventing herpes zoster. The vaccination target is adults aged 50 and over, and the immunization program is 2 doses.

Vaccination interval is 2 months, and the longest is no more than 6 months. Experts say that herpes zoster is a common disease in the elderly. To prevent the occurrence of herpes zoster, the first is to improve immunity, and the second is very important for middle-aged and elderly people to get a rash vaccine!

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For friends over 50 years old, it is recommended to vaccinate against herpes zoster, because with the increase of age, the probability of herpes zoster is getting higher and higher, and the incidence rate of people over 50 years old is obvious because of the gradual decline of cellular immune function, and active vaccination can reduce this risk. Vaccination is more recommended for people over 50 years old who have had chickenpox and their immunity is relatively low.

Do people who have had it still need to be vaccinated?

Experts say that people who have had herpes zoster once have a very low chance of getting sick again. The human body has a memory of herpes zoster virus immunity and will produce antibodies to avoid getting sick again.

However, people who have had herpes zoster and have relapsed still exist. Such patients often have very low immunity. After getting herpes zoster for the first time, they did not get enough antibodies. Therefore, when a similar situation occurs for the second time, the antibodies in the body are not enough to resist the virus, which will make the disease happen again. Therefore, for patients who have experienced herpes zoster recurrence, experts still recommend vaccination against herpes zoster to prevent recurrence.

Domestic listing enters countdown.

Throughout the world, there are two kinds of herpes zoster vaccines listed. Among them, shingrix from GlaxoSmithKline was approved to be listed in China in 2019 for preventing herpes zoster in adults aged 50 and over, and was officially launched in China market on June 28th, 2020, which is the only herpes zoster vaccine listed in China at present.

As herpes zoster vaccine belongs to the national immunization program, patients need to pay for it themselves. The price announced by Shanghai CDC is 1603.5 yuan/dose, and the full vaccination price is 3207 yuan, which is also the general price of community centers around the world, and the vaccination fee is not cheap. It is worth noting that at present, many domestic pharmaceutical companies are researching and developing the distribution of herpes zoster vaccine, and the fastest research and development company has received the Acceptance Notice of the application for the marketing license of live attenuated herpes zoster vaccine issued by the Drug Evaluation Center of China Food and Drug Administration. In other words, the vaccine has entered the stage of applying for marketing!

Source of this article: CCTV

Rush to the hot search! Yahoo Mail stopped serving in mainland China, and there was an early warning in November last year.

On the evening of 27th, a message # Yahoo Mail stopped serving in Chinese mainland on February 28th rushed to Weibo for hot search.

Yahoo said in the email that it can download backup emails, address books, schedules, etc. before February 28th, and it will not be able to receive and send emails or download data from Chinese mainland after February 28th.

In addition, PayPal has also sent a notice to users. If it is bound to Yahoo Mail, it needs to be changed to another email address as soon as possible.

In November last year, Yahoo China official website said that from November 1, 2021, users will not be able to use Yahoo’s products and services from Chinese mainland, and users in Chinese mainland will only be able to access Yahoo Mail, AOL Mail and Privacy Meter data from three given links. Subsequently, netizens found that Yahoo’s few online services that could be accessed in Chinese mainland were also stopped, including weather-related apps and news information, and the Chinese version of Engadget, a technology media owned by Yahoo, was also inaccessible.

It is worth mentioning that this announcement was released on November 2, and the behavior of stopping the service earlier than the announcement was also discussed by netizens. In fact, as early as 2013, Yahoo shut down news, e-mail, Chinese music and community services in Chinese mainland, and closed its research and development center in Beijing two years later, laying off more than 200 people.

According to statistics, in January, 2022, the market share of e-mail clients ranked first in Apple, second in Google Gmail, third in Microsoft Outlook and fourth in Yahoo. In 2017, when the information of 3 billion users of Yahoo was leaked, it was reported at that time that tens of millions of users were affected in China.

In the recent poll conducted on Weibo, users of QQ email account for the first place, followed by 163 email account and gmail email account, and only 299 people voted for Yahoo email account.

In 1995, Yahoo was founded. In 1996, Yahoo, which was founded only one year ago, went public. At this time, Yahoo’s market value reached 850 million dollars. Yahoo initially positioned itself as a media company, pioneered the free Internet model, and earned profits by establishing portals and selling advertising spaces. In 1997, Yahoo earned more than $70 million in revenue just by advertising. At its peak, Yahoo’s market value once exceeded $125 billion.

Yahoo entered Chinese mainland in 1998 and once occupied a considerable market share. According to iResearch- iResearch Market Consulting Report, in 2004, the market share of search traffic of China search engines was 33.1%, that of Yahoo! was 30.2%, and that of Google was 22.4%.

From 2000 to 2006, Yahoo occupied the first place in the global Internet company market value. However, with the rise of Google and others, Yahoo, whose empire was about to collapse in 2008, received an olive branch from Microsoft: it bought Yahoo at a premium of 60% to 45 billion US dollars, and Yahoo felt undervalued and refused; In 2017, Verizon, an American telecommunications company, acquired Yahoo’s core network business for US$ 4.48 billion, less than a quarter of Microsoft’s offer at that time. In 2019, Google bought Yahoo’s headquarters for $1 billion, and at the same time, Yahoo’s products began to withdraw from the China market.　

On May 4, 2021, Yahoo Q&A was completely closed. After that, visiting the website will directly jump to Yahoo’s homepage, and all the original content will disappear from the Internet. In November 2021, Yahoo China was officially closed; Today, Yahoo Mail completely stopped serving Chinese mainland.

(Titanium Media App Editor Wu Fengye Comprehensive national business daily and China Fund News)

After leaving the cabin again after 13 years, there is such a story behind the humble power handle.

CCTV News:When Shenzhou-12 finished its mission, it didn’t take much effort for Liu Boming to turn the handle to open the hatch. However, when Chinese astronauts completed the Shenzhou VII mission, it took a lot of effort to open the hatch. At that time, Liu Boming assisted Zhai Zhigang to get out of the cabin, but when he got out of the cabin that year, due to the pressure difference inside and outside the cabin, Zhai Zhigang could not open the hatch with great efforts. Later, in an interview, the Shenzhou VII flight crew described the situation at that time and their countermeasures.

On the afternoon of September 27th, 2008, when the eyes of the whole world were focused on China astronauts Zhai Zhigang and Liu Boming, an accident happened.

Liu Boming:I think Zhigang tried his best to pull the hatch. At that time, the hatch didn’t move at all. I feel very strange. Why can’t the hatch be pulled open when the ground is easy to do?

Zhai Zhigang:In the process of opening the door, I didn’t think that the force needed to open the door was so great at first, and I didn’t even think that the door would not be opened in the sky. Moreover, in the process of opening the door, I didn’t think that the door might be opened with great force, so I opened the door in a normal state throughout the process.

Liu Boming:At this time, it was very urgent to hear Zhigang’s breathing, because he consumed a lot of physical strength.

Zhai Zhigang:Finally, when my strength ran out and the door didn’t open, I found that I couldn’t open the door of Shenzhou VII air pressure cabin by my own strength.

Liu Boming:I went over and wanted two people to grab the handrail and pull the hatch at the same time, but the gloves were too big for two people to grab at the same time, so I had to put my hands around his right arm because he held the bulkhead with his left hand and pulled the hatch with his right hand. So it was the two of us at that time, and we almost pulled the hatch down with all our strength. The hatch was opened at an angle of 20 degrees. At this time, I felt the suction was particularly large. I felt that I was dragging the two of us up and the hatch was closed again.

Zhai Zhigang:This is a little anxious. If the door can’t be opened, then I will definitely not get out. If I can’t get out, the mission of Shenzhou VII will not be completed.

Liu Boming:At this time, it has flown into our measurement and control area, and the node for leaving the cabin has arrived, leaving us with little time.

Zhai Zhigang:In order to get out of the cabin, we have to pay too much, and we can’t open the hatch at the most critical time, so everything in front of the training is zero.

Liu Boming:In this case, I made up my mind, found the metal crowbar from the cabin and handed it to Zhigang, and then opened the hatch. At this time, the airflow instantly flowed out and the hatch naturally opened.

Zhai Zhigang:When the cabin door was pried open with an auxiliary tool, it was like opening a small window in an instant. At that time, an imaginary idiom was called be elated.

Zhai Zhigang:I’m out of the cabin and feel good!

Jing Haipeng:Liu Boming handed Zhai Zhigang the five-star red flag.

Zhai Zhigang:After Boming handed out the national flag, I didn’t think about anything else, so I showed it first.

Liu Boming:The five-star red flag is flying high in space, which proves that we have come to space.

This episode of Shenzhou VII did not appear in the extravehicular mission yesterday (July 4th). A booster handle on the Shenzhou 12 hatch makes it easier and smoother for astronauts to open the hatch. From this small power-assisted handle, we can see that our astronauts’ experience in getting out of the cabin is constantly accumulating, and the equipment used is also constantly improving. According to the plan, there will be another extravehicular activity during the Shenzhou-12 mission. We also wish the astronauts all the best in their work and life in space.